Imperfect storm: is interleukin-33 the Achilles heel of COVID-19?

The Achilles ’ Heel of CyberDefense

The Achilles' Heel of QBF

In recent years we have seen significant progress in the area of Boolean satisfiability (SAT) solving and its applications. As a new challenge, the community is now moving to investigate whether similar advances can be made in the use of Quantified Boolean Formulas (QBF). QBF provides a natural framework for capturing problem solving and planning in multiagent settings. However, contrarily to s...

Is BRAF the Achilles' Heel of thyroid cancer?

In this issue of Clinical Cancer Research , Ouyang et al. (1) present evidence suggesting that BRAF is a therapeutic target in thyroid cancer. Previous studies have shown that BRAF is mutated in a high proportion of thyroid cancers, but the therapeutic implications of this have not been investigated. In this article, Ouyang et al. show that small-molecule inhibitors of BRAF can block the growth...

Is survivin the potential Achilles' heel of cancer?

Survivin, the smallest member of the inhibitors of apoptosis proteins (IAPs), plays an important role in the control of apoptosis, cell division, and cell migration/metastasis. Survivin is expressed and required for normal fetal development but is then generally no longer present in most adult tissues. However, reexpression of survivin is observed in numerous human cancers where presence of the...

Is Arthropod Saliva the Achilles’ Heel of Vector-Borne Diseases?

establishment of a vector-borne disease. For example, tick-derived saliva factors appear to inhibit inflammatory cytokine secretion thus preventing efficient immune responses against tick-borne Rickettsia (4); a defined molecule in the saliva of the Aedes aegypti mosquito (SAAG-4) has the potential to alter the Th-profile of the bite-induced immune response likely rendering the host unable to e...